Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus

ABSTRACT

Treatment of impaired glucose tolerance, in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus comprises admin. of :(a)eg. a cpd. of formulae (I) or (II)(or a salt of these);(b) a cpd. of formula (IV) (or a cationic salt of (IV), or an acid addn. salt of (IV) when it contains a basic N atom);(c) a cpd. of formula (V) (or a cationic salt of (V), or an acid addn. salt of (V) when A or B is N);or (d) eg. a cpd. of formulae (VII) (or a tautomer, salt or solvate): R1, R2 = H or 1-5C alkyl; R3 = H, 1-6C aliphatic acyl,etc.;R4, R5 = H, 1-5C alkyl or 1-5C alkoxy; or R4+R5 = 1-4C alkylenedioxy; m = 1- 3; W = CH2 or CO etc.;Y, Z = O or NH; R11 = opt. substd. alkyl, alkoxy,etc.;L1, L2 = H or lower alkyl; or L1+L2 = alkylene;V = CH=CH, N=CH, CH=N or S; Za = H, 1-7C alkyl, 3-7C cycloalkyl,etc.;Z1 = H or 1-3C alkyl;q = 1- 3; A, B = CH or N, provided that they are not both N; X1 = S, O, SO2,etc.; s = 0-1; Y1 = CHR20 or R21; Z2 = CHR22, CH2CH2, CH=CH,etc.;R1y is not given; X2, X3 = H, Me, CF3, phenyl,etc. A2 = alkyl, opt. substd. aryl or opt. substd. aralkyl; A3 = a benzene ring with \~3 opt. substits.;R24 = H, alkyl, acyl, or opt. substd. aryl or aralkyl; or A2+R24 = 2-3C polymethylene (opt. substd. by alkyl or aryl, adjacent substits. together with the methylene carbon atoms opt. forming an opt. substd. phenylene gp.); R25, R26 = H; or R25+R26 = a bond; X4 = O or S; n = 2-6.



